Like "optimal-gender policy," the strategy of postponed consent also has a self-immunizing tendency, as it implicitly treats the small child's wishes as irrelevant.
These factors have helped to re-evaluate the rationality of the "optimal-gender policy," once recommended by John Money and others.
The new literature indicates a shift of the paradigm of a so-called "optimal-gender policy," a term coined by the early pioneering group in the field from Johns Hopkins University in the 1960s.
However, the underlying ethical principles of DSD management have not been seriously scrutinized since Kenneth Kipnis and Milton Diamond's harsh criticism in the Journal of Clinical Ethics of the "optimal-gender policy," particularly for the deficiencies in informed decision making [ 11].
30 Comparatively, another trial found that both 30 U and 50 U were safe and effective, although there was a slight improvement in treatment outcomes with the 50 U dose. 31 Kane et al propose that a standardized dose is not optimal since gender and muscle mass affect the dose required for efficacy.
The values predicted by these models were treated as the optimal values, given infant gender, gestational age, maternal height, parity, and age.
The few economic evaluations of methods for diagnosing UTI in young children [ 27, 30] have primarily evaluated 'which tests to use?' rather than 'who to test?' The 2006 HTA review [ 27] evaluated 79 permutations of dipstick, cultures, ultrasound, and MCUG, and identified four testing strategies most likely to be cost-effective, although the optimal strategy differed by gender and age group.
Optimal age- and gender-specific cut-off points for waist circumference to predict cardiovascular risk factors clustering are also proposed.
Receiver-operating characteristic analysis was used to derive the optimal age- and gender-specific waist circumference thresholds for predicting the clustering of cardiovascular risk factors.
