It should also be noted that the adjuvant dose when used in combination was not optimized but rather used at the optimal dose for each adjuvant alone.
It should be no surprise, then, that both the armed forces and sport scientists have tried to establish the optimal dose for their pilots, soldiers and sportsmen alike.
While the news about chocolate, especially cocoa, is encouraging, research hasn't yet identified the optimal dose for cardiovascular benefits.
Therefore, it is difficult to determine the optimal dose for a dietary program as part of a health policy aimed at improving hypertension health.
HSCs have great potential for regenerative medicine and are one decisive parameter for finding the optimal dose for chemotherapy of cancer patients.
We found that the extended mTPI design selects the optimal dose for safety and efficacy more accurately than the other designs for most of the scenarios considered.
Although many drugs require dose individualisation in clinical practice, dose-finding trials usually aim to identify an optimal dose for the patient population.
It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social behavior and cognition and what is the optimal dose for OT response.
More work will need to be done before the optimal dose for various individuals or groups can be determined.
The optimal dose for the triptans is mainly determined by tolerability.
Currently, there is no international consensus on the optimal dose for supplementation of vitamin D. European Food and Safety Authority recommends supplementation below 4000 IU/day [95].
