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DNA methylation profiles were generated using the previously described McrBC-based approach [25], [26], [27], Following statistical analyses, 220 loci were identified that provided optimal distinction between tumor and adjacent normal DNA samples.
We stratified on quartiles and median or mean of the characteristic to investigate the optimal distinction between groups.
These peptides have been chosen to give an optimal distinction between controls and patients with RA [ 6].
Combinations for optimal distinction between diseased and healthy were calculated separately for the discovery and verification sets, and for the whole collective using primary sum scores.
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This distinction between optimal AT- and optimal GC-ending codons indicates an effect related to base composition.
Case-control studies were included in the review only if there was clear distinction between optimal and poor glycaemic control in relation to outcomes in the cases (patients with diabetes).
Although, it would be optimal to provide distinctions between all factors that represent sex and gender, disentangling sex from gender may not be always possible and therefore more complex factors were examined as "sex/gender" interactions.
The problem is that as technology blurs the distinction between illness and optimal health, it becomes increasingly difficult to distinguish normal from abnormal.
This literature mainly deals with the optimal amount of investment or with the distinction between specific and general human capital.
The optimal surgical management remains controversial and a clear distinction between indications for one of both treatment options cannot be made on the basis of the current evidence in the literature.
The optimal assessment instrument should allow for a clear distinction between symptoms primarily associated with the disease and those associated with consequences of the disease validated for the target population.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com