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The diagram showed an optimal dissolution region for EC operation.
The design of amorphous formulations with optimal dissolution performance requires the appropriate selection of a combination of excipients and consideration of the method of introducing the excipients.
After the comparative analysis of the results, optimal dissolution conditions were determined as follows: water as dissolution medium, paddles at the stirring speed of 50 rpm as apparatus and time of 30 min.
The results of the current study indicate that supersaturation greatly improves drug loading and that 16 25% w/w is the optimum loading level which retains optimal dissolution behaviour for the oral delivery of ibuprofen, which has the potential to be translated to other poorly water-soluble drugs.
In addition, as mucociliary clearance functions only in the upper regions of the lung, an optimal dissolution rate to maximize such pulmonary targeting was also identified (Tayab & Hochhaus 2005; Weber & Hochhaus 2013).
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The enhancement, nevertheless, depends on the values of the multicomponent diffusion coefficients and may exhibit an optimal condition for dissolution due to the impact of CO2 diffusion and entrapment into matrix oil.
Increasing the urine pH to around 6.5 provides optimal conditions for dissolution of uric acid stones.
As a next step, an investigation into the passivation behaviour of the NiAl was performed in order to determine the optimal potential for wire dissolution.
Emphasis is placed on the influence of fines dissolution on the optimal operating conditions.
However, the non optimal deposit shows a preferential dissolution of IrO2.
The results showed that the optimized formulation provided a dissolution pattern equivalent to the predicted curve, which indicated that the optimal formulation could be obtained using response surface methodology.
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