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It is the resultant from the individual optimal directions of all directed interactions which are connecting one residue with the ligand.
It means that we can firstly determine the optimal directions of w R and w J and then seek the optimal power allocation between w R and w J. Furthermore, given a fixed w R, we just need to search the optimal w J in a space with lower dimension than w and vice versa.
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QSAR and molecular docking models provide insight into the mechanism of inhibition and indicate the optimal direction of future synthetic efforts.
On the foundations of that empiricist ideal has risen a global political and economic system, dedicated to the proposition that individuals are the best judge not only of their own interests, but of the optimal direction of a civilization.
Stimuli with reversed polarity offer an alternative method of delivering control stimuli when an optimal direction of stimulation is known for the brain region of interest.
To determine the optimal direction of the osteotomy, we assessed ankle radiographs and computed tomography (CT) scans.
After initial hand-plotting of the receptive field in relation to the fovea, drifting achromatic (luminance modulated) sine-wave gratings were used to establish the optimal spatial and temporal frequencies and optimal direction of movement, except in cases where achromatic gratings gave poor responses.
In particular, the optimal direction for the initial value of (3) can be found by the following procedure.
Each pre-selected sample tree was located in the field and examined to determine the optimal direction to get the clearest view of the stem and branches.
One simple technique is gradient descent such as maximum likelihood (ML) [13, 14] and maximum a posteriori (MAP) with iterative projection [15], another is a dual version derived from its Lagrangian proposed by Lee et al. [16], the method of optimal directions (MOD) [17] proposed by Engan et al. is also a common technique which solves it using the pseudo inverse of X.
That is, the optimal direction was that of the eigenvector corresponding to the largest eigenvalue of matrix R.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com