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This paper aims at extending the evolutionary structural optimization (ESO) algorithm to optimal contact shape design for elastic bodies under the multiple load cases.

In this paper, the optimal contact shape is studied by formulating several classes of shape optimization problems, namely minimization of generalized wear volume rate, friction dissipation power and wear dissipation rate occurring in two bodies.

optimal contact between cancellous graft and living cancellous bone.  .

Therefore, 180 min was set as the optimal contact time for adsorption process.

In this study, an optimal contact lens design for myopia and astigmatism eyes was proposed.

A roughly optimal contact length (LC) of LC0 ≈ 6tSC is obtained.

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The improved electrochemical performance is attributed to the synergetic effect of the large accessible surface area and optimal contacts between the MoS2 and the electrolyte, as well as high capacitance of the metallic Ni3S2 core.

L226 and S228 make optimal contacts with SA α2,6-linked to the Gal of a human glycan receptor [26].

The recently solved X-ray co-crystal structures of avian and human H2 HAs with representative α2,3 and α2,6 SA liked glycan receptors [26] provides insights into the key amino acids involved in optimal contacts with these receptors (Figure 3).

Homology-based structural investigations [17], [21] suggest that A/H1N1/2009 HA has the necessary residues to provide optimal contacts for high affinity binding to α2-6 sialylated glycans present in the human upper airway [22], while it apparently shows minimal contact with α2-3 sialylated glycans present in the human lower respiratory tract [23].

The 220-loop of NY18 HA makes fewer contacts with the human receptor and NY18 HA also lacks the longer side chain of Glu for optimal contacts with the avian receptor.

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