Thus, if a single protein length peptide set is used, consensus or COT peptides are optimal for detecting responses, yet the breadth of T cell responses is extended with the use of coverage-optimized peptides.
Taken together, these data demonstrated that the limited neutralization profile of antibodies induced by optimal subtype B V3 motifs likely represents the maximum breadth of neutralization of subtype B HIV-1 primary isolates attainable by anti-V3 peptide antibodies.
Thermodynamic binding energy predictions, conservation and uniqueness scores must be computed for millions of candidate probes, in order to select an optimal combination of probes for each target gene family, balancing sensitivity, specificity, and breadth of coverage.
In view of these complexities, optimal assessment and management is best undertaken by specialist units able to provide the breadth of expertise and options required.
The satisfactory results obtained highlighted the breadth of applicability of the proposed approach especially for new designs or for optimal rating of existing equipments.
First, the depth and breadth of sampling for oral microbiota have been insufficient in general, and the optimal parameters not determined for that of gingivitis patients in particular.
The breadth of opposition is hardly surprising.
Such is his breadth of view, his breadth of vision, his breadth of influence.
He covers a remarkable breadth of topics.
The breadth of skill is often impressive.
