Sentence examples for optimal binding affinity for from inspiring English sources
The aim of this study is to propose a series of novel [60] fullerene-based inhibitors with optimal binding affinity for the HIV-1 PR enzyme.
These compounds were initially evaluated for histamine H3 receptor binding affinities, suggesting that a propoxy chain linker between the amine and the core ring could be essential for optimal binding affinity.
Since it has been shown that this modification reduces the binding activity of annexin [8], and also, that all four domains present in anxA5 are necessary for optimal binding affinity [9], it is important to ensure that the binding properties of anxA5 are not impaired by these reactions.
These results indicate that for optimal binding affinity a ligand should contain a hydrophobic side chain as well as a (partially) negative charge.
For example, VEGF165 binds HS through two highly sulfated S-domains flanked by transitional regions [8] indicating that VEGF165 perhaps require much longer species of oligosaccharides for their optimal binding affinity.
Analysis of the binding database for existing clinical and experimental inhibitors has allowed us to address the following questions in a quantitative fashion: (1) Is there an optimal binding affinity?
However, modifications in the binding loop to achieve specificity may compromise structural rigidity and prevent re-engineered inhibitors from reaching optimal binding affinity.
The optimal decoy receptor fusion protein with the highest binding affinity for FGF-2 was identified by an FGF-2-binding assay and its potential antitumour effects were investigated.
The identified IQ-tag peptide (IQSPHFF) is unique and has a sub-nanomolar binding affinity for the NIR fluorochrome GH680, due to a number of optimal binding interactions between the peptide and benzindolium dye.
Binding affinity in both human and canine prostate most significantly correlated with binding affinity for the recombinant bovine alpha-1C receptor (r =.98 human,.95 canine).
The presence of the toxic enzyme inside the cocoon is essential for its subnanomolar binding affinity for the TcA subunit.
