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Nonetheless, innovative delivery systems will be necessary to ensure optimal application of chronotherapeutic interventions.
Another key issue considered is the optimal application of parallel computing.
Simplified models yet with a good predictive capability are extremely useful in the optimal application of these devices.
Another key issue addressed is the optimal application of parallel computing and the implementation of less time consuming tally estimators.
However, an improved quantitative understanding of landward transport is required for optimal application of the proposed method.
Thus, urban agriculture may not be the optimal application of space in northern cities to improve urban environmental performance.
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Examples of deviations from guidelines are: no or delayed consultation of the obstetrician in case of suspected fetal growth restriction, no fetal monitoring in case of induction of labour, expectant management in case of non-reassuring cardiotocography and non-optimal application of the guideline for resuscitation of the new born.
We simulated the optimal application timing of the measures by assuming that the interventions were implemented prior to the introduction of the first infected case and continued indefinitely.
Additional studies are required to delineate the optimal application and interpretation of results based on Cohen's h.
Eventual optimal application will depend on specifications of specific target groups.
We thus propose the following directly relevant principles from this approach as an ethically robust and pragmatically useful framework for exploring and converging on protocols for the optimal patient application of surgical implants: (I) human dignity and human rights, (II) benefit and harm, (III) autonomy and consent, and (IV) justice.
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