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On the other hand, in the last twenty years, GA is attracted as one method which gives us optimal answers for global search, optimization and machine learning problems.
A GA-based optimization process improves these chromosomes gradually yielding a set of mostly optimal answers for the MSA problem.
A mistake some students make is to assume that there is one correct or optimal answer to an essay question and that the sequence of words for a correct answer cannot be "owned" by anyone.
Thus neither screening nor the treatment available gives an optimal answer to this problem.
But many policy decisions don't have an optimal answer.
Sometimes, the simple straight-forward most obvious answer turns out to be the optimal answer.
Normally, when solving MSA problems, the optimal answer is unknown and there is no concrete criterion to evaluate the quality of a given algorithm, unlike the case for Pair-wise alignment where an optimal solution can always be found.
The short answer is that "on-demand" is not the optimal solution for most customer needs. .
However, our study design, where we measured HRV cross-sectionally, is not optimal for answering this question.
When the necessary conditions for a BIBD are satisfied, but no BIBD exists, there is no simple answer for the optimal design problem.
When the necessary conditions for a balanced incomplete block design (BIBD) are satisfied, but no BIBD exists, there is no simple answer for the optimal design problem.
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