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Given the opposite selection pressure of CQ and MQ/ART on pfmdr1, addition of CQ to ART treatment may improve the efficacy of ART, although CQ alone is not effective in many parts of the world.
We acknowledge that it is unknown whether or not the most associated SNPs are causative; leading to confusion when we discuss selection for risk-associated alleles as the causal SNP may show the opposite selection pattern, that is, stronger selection of the protective allele.
Previously, Notch had appeared to be the only locus with opposite selection pressures between these lineages.
The two traits are thus under opposite selection pressures, with tibia length experiencing relatively greater directional selection pressures.
Overall, our results indicate that simple and com1plex ASEs are under opposite selection pressure for protein reading frame preservation.
However, protective immune responses against malaria impose the opposite selection pressure [ 46], and the relative strengths of these potentially conflicting effects of immunity remain to be investigated.
Similar(45)
For some reason, though, when they were both offered frozen desserts, they tended to make opposite selections — ice cream for one, frozen yogurt for the other.
The balance of these opposite selections may make the results sensitive to slight variations in conditions.
Second, the heterozygote advantage arises because of the super-position of two opposite directional selection pressures (malaria and sickle-cell anaemia), so it is not really a true case of heterozygote advantage arising from the heterozygote having superior fitness for a specific trait.
One possibility is that there is opposite purifying selection on the upstream regulatory region and the protein-coding region.
Although combination of antimalarial compounds with opposing resistance mechanisms have been used to suppress the emergence of drug resistance in laboratory isolates, 167 opposite resistance selection has also been observed in the field between 4-aminoquinolines (chloroquine, amodiaquine) and artemisinins.
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