Remarkably, BRE expression showed opposite effects on prognosis.
However, in some cancer types multiple anti-apoptotic proteins are expressed [ 9], and have opposite effects on prognosis [ 10- 12] indicating that there may be subtle, but clinically and biologically relevant functional differences between family members.
In these cases, the early effects that are relevant for prognosis are opposite to the late effects, where a longitudinal trend affects fitness.
Studies of Bcl-2 family protein levels in colon cancer samples identified opposite correlations between patient prognosis and Bcl-2 or Mcl-1 protein levels using IHC.
Our previous study demonstrated that HNRNP G and HTRA2-BETA1 trigger opposite effects on EC prognosis: a simultaneous higher level of HTRA2-BETA1 proteinuclearar expression as well as mRNA is correlated to poor disease-specific as well as progression-free survival.
PNA staining does not have any prognostic significance [ 26], while a more recent study using the mAb A78-G/A7 showed a correlation of T-antigen expression with a better prognosis [ 28], opposite to what is reported for gastrointestinal, lung or cervix cancers.
In another study, expression was linked to poor prognosis, showing the opposite trend [ 45].
21, 33, 35 Even among head and neck cancer patients, interpretations of the relationship between autophagy and prognosis were diametrically opposite.
For example, CTGF expression in acute lymphoblastic leukemia, breast, pancreas and gastric cancer correlates to worse prognosis whereas the opposite is true for colorectal, lung and ovarian cancer.
The middle portion contains 10 genes of the opposite direction (over expression → good prognosis).
