Exact(1)
Reflecting the mutually opposing interplay that has been reported between SMAD2/3 and SMAD1/5/8 signaling (52, 53), blocking of the SMAD2/3 pathway alone with an inhibitor of the receptors ACVR1B/TGFBR1/ACVR1C resulted in a similar level of differentiation to BMP4 alone.
Similar(59)
Everything the actress does is a triumph of artifice – she is like a walking metaphor – while Burnaby is doggedly literal, so that, at some level, their interplay describes opposing efforts to put life into language.
That evidence is the interplay of opposing states and forces, which Heraclitus points to by claims about the unity of opposites and the roles of strife in human life as well as in the cosmos.
The good news is there is a third option: to engage things more deeply, bringing our passion and energy and intelligence to bear on creating a whole that includes us, although it may not be controlled by us, a whole that evidences a harmonious interplay of opposing forces.
Much like our Bible, which relates how God created heaven and Earth from a void, classical Chinese cosmology describe a still and empty ether, pregnant with infinite possibility, from which the world spontaneously organized into the harmonious interplay of opposing forces we see today.
These data reveal the remarkable interplay between opposing signals embedded within ERAD substrate molecules and the mechanisms that decipher them.
The evolution of gene order in fungal mitochondria, particularly in basidiomycetes, suggests a complex interplay of opposing evolutionary forces.
Interestingly, myofibroblast differentiation appears to be subject to opposing regulation via complex interplay between NOX4-derived H2O2 and NO signaling.
The endothelial vasoregulation is based on the interplay between opposing vasoconstrictive mediators (e.g. plasma endothelin-1 [EDN1], thromboxane [TXA 2], methyl arginine, transcription factor HIF-1α [hypoxia-inducible factor 1-alpha] and acetylcholine) and vasodilating agents (e.g. prostaglandin [prostacyclin], CGRP [calcitonin gene-related peptide] and eNOS [ 102- 104].
Combined with nuclear magnetic resonance and isothermal titration calorimetry data that revealed altered binding of the analogue to the K170M mutant, these structures suggest a model of Schiff base formation characterized by the dynamic interplay of opposing forces acting on either side of the substrate.
We present a mathematical model which implements the interplay between two opposing selection pressures; one that favours virulent (high-dominance) VSAs in non-immune hosts, the other facilitating non-virulent (low-dominance) VSAs that allow chronic infections in individuals with substantial VSA-specific immunity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com