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ERK and JNK/p38 have opposing functions, whereas ERK are generally pro-survival and SAPKs pro-apoptotic.
The reconciliation of these somewhat opposing functions is challenging.
Uematsu and colleagues were the first to find that the locus coeruleus has multiple opposing functions.
Most of these activities are largely regulated by its molecular weight, which often triggers opposing functions.
Thus, Bmi1 and Mel18 have opposing functions and are present in distinct complexes.
Boruchov, A. M. et al. Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions.
The goal of this study was to determine how PI-3 kinase-Akt signaling regulates these seemingly opposing functions.
CaMKIIδ and -γ isoforms have opposing functions at the level of cell cycle regulation, proliferation, and VSM hyperplasia in vivo.
Our results further strengthen the argument that different Akt isoforms might have distinct, even opposing functions in the regulation of cell growth or migration.
The leukotriene A4 hydrolase (LTA4H) is a bifunctional enzyme, containing a peptidase and a hydrolase activity both activities having opposing functions regulating inflammatory response.
These opposing functions displayed by bZIP TFs, are still unclear.
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