This multi-position metal switch constitutes a new paradigm in bifunctional enzyme regulation, in which the relative concentrations of specific metals for the AMPylation and deAMPylation configurations tip the balance toward opposing activities within the same active site.
These opposing activities may represent a self-limiting activation of ECM remodeling, which represents a novel potential bystander response.
The SOS response, the prototypical response to DNA damage in prokaryotes, is controlled by the opposing activities of the LexA repressor and the RecA activator proteins [53].
Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death.
Tian, H. et al. Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis.
Tian, H. et al. Opposing activities of notch and wnt signaling regulate intestinal stem cells and gut homeostasis.
Cunningham et al. characterize the ubiquitin chain linkages regulated by the opposing activities of the E3 ligase parkin and the deubiquitylation enzyme USP30 on mitochondria.
Macrophage subpopulations perform opposing activities in muscle regeneration.
The opposing activities of HATs and HDACs can modulate the activities of diverse transcription factors and regulatory proteins (Glozak et al., 2005; Wang, 2011).
Through their opposing activities, the initiator E2, Ube2w, and the specialized deubiquitinating enzyme (DUB), ataxin-3, participate in initiating, regulating, and terminating the CHIP ubiquitination cycle.
His studies contributed to the discovery that bacterial supercoiling is homeostatically regulated by topoisomerases having opposing activities and that environmental conditions (oxygen tension, salt concentrations) can alter global supercoiling levels.
