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Opportunity knocks but once.
This idiom means that you only get one chance to achieve what you really want to do.
Exact(34)
When he returned to New York, opportunity knocked.
Three years ago, opportunity knocked again.
Ramsey was not so generous when opportunity knocked.
When opportunity knocked again for Balotelli, he failed to connect with Moreno's ball across goal.
But when opportunity knocked for Wilson he seized it with a vengeance.
Opportunity knocked for Purdue a day after losses by No. 1 Kansas and No. 2 Kentucky.
Similar(23)
If opportunity knocks he should seize it.
Speaking as a bona fide, fully existent critic, I hear opportunity knocking.
Nothing in this recital of deprivation hints at any sort of opportunity knocking.
To borrow a phrase also useful in poker: "Opportunity knocks, but it doesn't pester".
"My grandfather used to say, you know, opportunity knocks at everybody's door at least once.
More suggestions(1)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com