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Patients who were able to discontinue infliximab were younger, had lower mTSS and had shorter disease duration, further supporting the window of opportunity hypothesis.
The ongoing RTCs on dementia prevention will have to take into account the 'window of opportunity hypothesis' when evaluating the results of interventions.
Recent empirical studies of the impact of sex distributions in workplaces find some evidence for the "macro-structural opportunity hypothesis" (McKinnish 2007; Svarer 2007), but this study clearly does not.
The selection opportunity hypothesis [ 10] predicts not only that the average rate of change must increase over developmental stages, but also that the proportion of genes showing evidence of positive selection should increase with subsequent developmental stages [ 43].
The "selection opportunity" hypothesis suggests that later stages in ontogeny give rise to greater opportunity for selection to act due to the exposure to varying environments (Darwin 1872; Gould 1977).
Based on the overall results, it remains unclear if achieving biologic-free and drug-free remissions are primarily due to the natural course of the disease or to the early therapeutic intervention according to the 'window of opportunity' hypothesis.
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However, a gradient in these divergence rates over development is predicted by both the developmental constraint and selection opportunity hypotheses and thus evidence supporting either or both will be considered below.
So if the window-of-opportunity hypothesis has any urgency, it might be with that disease.
According to the 'window-of-opportunity' hypothesis, DMARD treatment should ideally be initiated within three months of symptom onset in high-risk patients [ 30].
And it gives researchers a great opportunity for hypothesis generation, which I think can shake up the field in good ways".
NPC has a highly unusual global geographic distribution, and thus provides a particular opportunity for hypothesis generation and testing.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com