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Content analysis is a scientific methodology and thus reliability, validity and the opportunity for replication are central advantages of using it as an analytical tool.
Therefore we speculate that unactivated parenchymal cells offer invasive bacteria a window of opportunity for replication and further dissemination.
This observation is likely the consequence of the increased polymorphism observed within genes involved with host interaction reducing the opportunity for replication slippage to occur.
Cross-sectional data prohibits causal inference, though follow-up of the participants across time will allow the opportunity for replication of this study with a longitudinal design.
These relationships are also understandable because more motifs, larger motif repeat number and longer repeat length give more opportunity for replication slippage.
In addition, the design of our study creates an opportunity for replication in other centers in an effort to compare and contrast the information needs among providers in various NICU settings.
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While it's still early days, Green says the model of a university, industry bodies and commercial partners collaborating closely to identify an as yet untapped global graduate opportunity, and together developing a tailored response, is one that offers interesting opportunities for replication.
Finally, the collaboration by CHARGE study investigators with other population-based autism epidemiologic efforts currently under way, such as the national Centers for Autism and Developmental Disabilities Research and Epidemiology CADDREE) study, will create valuable opportunities for replication and perhaps data pooling.
In humans and chimpanzees, microsatellite loci with interrupted repeat regions had a two-fold decrease in the mutation rate, which was interpreted as being due to interruptions reducing the opportunities for replication slippage [ 6].
As both the BRCA1 and BRCA2 proteins are involved in postreplicative DNA repair (Brodie and Deng, 2001; Deng and Brodie, 2001; Kerr and Ashworth, 2001), reducing the proliferative activity of the breast luminal epithelial cell population from which most tumours are derived should reduce the number of opportunities for replication errors to occur.
Therefore, until the opportunity arises for replication in independent samples, especially in large numbers of comparable White European adults, caution is needed in interpreting these results.
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CEO of Professional Science Editing for Scientists @ prosciediting.com