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"We were underweight the stock for most of last year, mainly on concerns for the quality of its opportunities upstream," he said, referring to Shell's ability to find and produce oil and gas.
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At the same time, companies' rising interest in the basic mechanisms of disease creates opportunities for "upstream" research.
In patients with a shorter history of AF and the underlying disease, remodelling processes are assumingly less advanced, providing greater opportunity for upstream therapies to be effective.
Robert Gannicott, chairman and chief executive of the Harry Winston Diamond Corporation, said the sale "will leave us well equipped to realize upstream opportunities in an environment where cash has become a strategic resource while preserving and expanding our relationship with the downstream diamond business".
This paper reports on findings from an action research project in Philadelphia aimed at exploring opportunities for enhanced upstream engagement.
2) Look forward in the value chain (after thinking about upstream opportunities as well).
Other related studies have indicated that where upstream opportunity costs are high and downstream benefits are low (Pagiola and Platais 2002), PES schemes tend to be unsustainable.
Likewise, Ndetewio et al. (2013) found that equitable Payment for Ecosystem Services become sustainable and feasible if downstream benefits are high and upstream opportunity costs are low.
The observed link between K-supply and LOX2 therefore provides a new opportunity to identify upstream components of oxylipin signaling.
It is precisely this signaling diversity that offers an opportunity to target upstream kinases in the JNK cascade that regulate pathogenic responses in arthritis while potentially sparing other functions that are critical to host responses.
Four recently discovered mouse strains provide opportunities to decipher mechanisms upstream of synoviocyte activation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com