The protocol can be fine-tuned by choosing opportune targets (biological or not) and molecular descriptors, and it can be useful in every fields in with it is possible to collect set of compounds with known properties.
The generation of CCR5+ memory and central memory CD4+ T cells in response to the malaria parasite would be opportune targets for SIV infection [41].
Recent observations using fluorescence correlation spectroscopy have identified that both A32- and C11-like epitopes become exposed within minutes of incubation of HIV and target cells, further validating that these CD4i epitopes are opportune targets of the humoral immune response at extremely early stages of HIV infection (Mengistu et al., 2015).
Several Republicans, including former House Speaker Newt Gingrich and Representative Peter King, have found it politically opportune to target "creeping Shariah in the United States" at a time when the middle name of the president is Hussein.
Thus, EMT regulators like Twist, Snail, or FOXC2 transcription factors, self-renewal pathways like TGF β, Wnt, and Notch that are known to induce EMT, or microRNAs like miR200, miR155 involved with EMT may prove to be opportune therapeutic targets.
The activists reportedly said that the World Cup offered an unprecedented global audience and an opportune moment to target sites operated by world football's governing body Fifa, the Brazilian government and corporate sponsors.
"The most opportune time for Target to sell its portfolio may have passed, in our opinion, she added, but recent macro issues may have led management to reconsider its stance on owning the business".
Kindergarten was also seen as an opportune setting to target parents for early dental advice in group sessions.
Nearly a century later, in September 2011, the drone strike slaying of militant propagandist Samir Khan was explained as an opportune moment: The main target was terrorist suspect Anwar Awlaki, and Khan was nearby.
