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Identifying and understanding the biological features characterizing operational tolerance may unveil molecular mechanisms allowing such patients to tolerate their graft without immunosuppression treatment.
Roedder, S., Gao, X. & Sarwal, M. M. The pits and pearls in translating operational tolerance biomarkers into clinical practice.
Martínez-Llordella, M. et al. Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients.
Bohne, F. et al. Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation.
Regulatory T cells (Tregs) which may indicate operational tolerance provide a promising biomarker for individualization of immunosuppression.
Occasionally, kidney transplant recipients develop a state of targeted immune quiescence (operational tolerance) against an HLA-mismatched graft, allowing them to withdraw all immunosuppression and retain stable graft function while resuming immune responses to third-party antigens.
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Mixture variables were kept within specified limits as per allowable operational tolerances, and performance was monitored through the evaluation of the results obtained from volumetric properties and laboratory tests, such as flexural fatigue test, Hamburg wheel-tracking test, and overlay tester.
Interestingly, and in contrast, novel data suggest that B cells may play an important role in allograft survival and the development of operational transplant tolerance (reviewed in Ref. 3).
This approach results in a modular control hardware architecture since no wire connections are used between the actuators and sensors in each of the mobile robot subsystems and also provides operational fault-tolerance.
This ensures the recording head never touches the disk surface resulting in improved long term reliability due to less head wear, and improved non-operational shock tolerance.
Brouard, S. et al. Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance.
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