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Based on our definition (see background), we developed a pre-specified, three operational pathway criteria as follows: 1) multidisciplinary (two or multiple clinical professions involved), 2) protocol or algorithm based (i.e. structured care plan/treatment-protocol or algorithm) and finally, 3) evidence based (pathway components were minimally based on one RCT or best practice guidelines).
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We assembled a multidisciplinary team to address the nature of these incidental findings and designed new workflows and operational pathways for both radiology and ED staff to properly communicate incidental findings.
Thus network reconstruction and constraints-based analysis identify condition-dependent operational pathways that throw light on adjustments the organism is capable of making in different environments.
Previous metabolic analysis of the model pathogen Salmonella [ 5], which displays greater variability of its metabolic pathways during intracellular growth, revealed alternate functional pathways that are operational during infection.
In a fully operational proteolytic pathway, potentially harmful oligomers can be tagged and destroyed before inducing a cascade of toxic effects.
A potential operational solution (pathway-based DDD), based on observability rather than predictability, is described, focusing on emergent properties of key metabolic pathways in vivo.
Pneumocystis pneumonia is recalcitrant to treatment with standard anti-fungal therapies that target ergosterol synthesis, which raises important questions as to the function of an operational sterol biosynthetic pathway in these organisms.
23 As a RER+ endometrial cancer cell line, HEC-1-A has an operational TGFβ-signaling pathway.
In addition to providing a glimpse into the biochemical pathways operational during infection, our study has also revealed potential diagnostic markers and possible drug or vaccine candidates against this neglected disease.
These links and their operational channels and pathways are actively constructed, planned, governed and maintained.
Indeed, blocking the inhibitory pathways operational in the microenvironment results in enhanced T-cell-dependent, anti-tumor immunity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com