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Another is to gain a better understanding of the "transcriptome" (also called the "RNAome")—the expression of all regulatory elements operating to regulate the expression, stability, and translation of transcripts (strands of RNA) in the cell.
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Exposure to very low levels of elements such as lead, cadmium and mercury have been shown to have a cumulative effects on humans since there is no homeostatic mechanism that can operate to regulate the levels of these toxic substances (Carter and Fernando 1979).
Clearly, our data indicate that Hedgehog pathway and Notch pathway activity can co-operate to regulate neurogenic divisions of neocortical progenitors.
Our results demonstrate that mechanistically distinct pathways operate to regulate apoptosis in mammalian cells under basal (physiological) versus stress-induced conditions.
The possibility that such reciprocal interactions might operate to regulate PD identity after amputation is now open to experiment.
An intricate network of epigenetic mechanisms operates to regulate the chromatin state and thereby transcription (Fig. 1).
To produce the correct number and types of neurons, a population of proliferating progenitors is maintained throughout neurogenesis and several mechanisms operate to regulate their differentiation.
For example, they co-operate to regulate TRX2, a cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative stress (Güldener et al. 2005).
Parallel studies carried out in human cells support the notion that similar principles operate to regulate the activities of their orthologs in higher eukaryotes.
When both HIPPI and P53 were co-expressed, the expression of Caspase1 was strongly enhanced compared to the corresponding single transfected cells indicating that both the transcription factors co-operated to regulate this gene expression.
Because GluD1, which is closely related to GluD2, and PTPMEG are coexpressed in regions outside the cerebellum, similar signaling mechanisms may operate to regulate LTD inducibility at other synapses.
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