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The phrase "operating downstream" is correct and usable in written English.
It refers to someone or something that is following the decisions made by someone or something else. For example, "The financial analyst was responsible for operating downstream of the Board's decisions."
Exact(27)
To better define the gene network operating downstream of Math5, we used custom-designed microarrays to examine the changes in embryonic retinal gene expression caused by deletion of math5.
A generality that has emerged in the last decade is that representatives of many major classes of plant defensive metabolites are inhibitors of signal-regulated protein kinases operating downstream from hormone or neurotransmitter receptors in animal and fungal signalling pathways.
Phylogenetic comparison of rice and Arabidopsis WRKY families revealed that OsWRKY81 was clustered with AtWRKY18 in WRKY subgroup IIa, which functions in the positive regulation of basal defense and systemic acquired resistance (SAR) operating downstream from NPR1 in Arabidopsis (Wang et al. 2006).
The data illustrate potential autocrine/paracrine and transcriptional networks operating downstream from the initial stimulus, ET-1 (Fig. 7).
β-catenin, operating downstream of WNT4 in the somatic cells, acts as a suppressor of activin βB, which is a negative regulator of female germ cell survival.
Therefore, both overexpression of CYCD3.1 and reduction of RBR bypass the cell cycle arrest mediated by inactivation of ABP1 in root cap stem cells, suggesting that the CYCLIN D/RBR pathway is operating downstream of ABP1.
Similar(33)
Two parallel rapid dual-media filtration units (anthracite or pumice and sand) are operated downstream.
This difference is mainly caused by a better utilization of chromatography resins in the continuously operated downstream.
Isocitrate dehydrogenase, which operates downstream of citrate in the TCA cycle and operates in an oxidative manner with NAD(P +, could not be used.
This latter finding was properly interpreted with the hypothesis that GTN induces migraine, rather than by releasing CGRP, by a mechanism that operates downstream with respect to CGRP.
Contrary to the upstream part, the continuously operated downstream is about 8 €/gmAb cheaper than the downstream of the batch process.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com