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Subsequently, HIF was identified as the novel transcription factor that operates this enhancer; it too was found to be widely expressed and operative [ 2, 3].
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Weasels operate this way".
"He's always operated this way".
Thus, the zinc finger family genes can operate as enhancers or repressors of gene expression; depending on their action, they may have high or low expression levels in neoplastic tissues.
This enhancer was also not evolutionarily conserved (Figure 2).
This enhancer is distinct from previously identified enhancers of Neurog2 (Scardigli et al., 2001).
This enhancer was crucial for expression in embryonic cartilage.
This enhancer maintaining activity may be shared amongst KDM5 enzymes, as KDM5B also appears to restrict the spreading of H3K4me from enhancers, contributing to normal enhancer activity [ 131].
DOI: http://dx.doi.org/10.7554/eLife.00170.013 To determine mechanisms by which TAF7L operates via its occupancy at enhancers, we probed its potential association with adipocyte-specific enhancer binding transcription factors.
In summary, we propose that enhancers operating at reduced activities ('weak enhancers') can function in an additive manner due to relatively infrequent interactions with their target promoters.
The impact of chromatin structure and nucleosome positioning is not included in our function model, which operates under the assumption that the entire enhancer is an "open chromatin" region; this assumption is true only to a first order of approximation.
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