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This new prototype sensor operates in the reflection mode rather than the transmission configuration utilised in the previous DOE-based liquid purity sensors, which were not hand-held devices.
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The system is composed as a periodic chain of nonlinear fibers with negligible intrinsic group-velocity dispersion (GVD), alternating with sections of unchirped fiber Bragg gratings (FBGs) operating in the reflection regime.
The chemical structure of nanofibers was conducted with a Fourier transform infrared (FT-IR) reflection spectroscopy (NICOLET, Thermo Fisher Scientific, Waltham, USA), and a X-ray powder diffractometer (XRD) (D8 Advance, Bruker, Karlsruhe, Germany) operated in the reflection mode with Cu-Kα radiation in the 2θ range of 10° to 80° with a rate of 4°/min.
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MALDI-MS was performed using an Ultraflex TOF/TOF system (Bruker Daltonics) operated in the positive ion reflection mode.
When the fluorescence microscope combined with the tip-scan HS-AFM instrument is operated in the total internal reflection mode, simultaneous single-molecule HS-AFM/fluorescence microscopy observations can be performed, as demonstrated.
Traditionally the technique operates in reflection geometry with a polychromatic X-ray beam focused to a sub-micron spot and with photon energy ranging from approximately 5 to 30 keV.
The system operates in reflection mode.
After 30 min incubation with six antigens of varying concentrations, immunoglobulins A, D, G, and M (IgA, IgD, IgG, and IgM); C-reactive protein (CRP); and fibrinogen were detected by an LSPR setup operating in the reflection mode.
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