In many developing nations, contamination of municipal water supply systems by faecal bacterial pathogens has become a public health hazard, because often there are not enough resources (cost, capital or commitment) to install or to operate functional municipal water systems leaving the civil society to resort to alternatives, one of which is packaged water.
Given that planned UNICEF BCO outputs were generally quite significant in terms of expected achievements (e.g., decentralized primary education and management practices at school, upazila and district levels; local government and other relevant institutions operate functional birth registration system) it would seem very important to report on their cumulative achievements over time.
Long operated as functional monopolies with attractive margins, local papers have undergone a nosedive in earnings and advertising revenue.
In those cases where σ(t) acts on a time scale similar to that of the functional mode (i.e., τσ≈τf−Scenario 2), σ(t) may be said to operate the functional mode.
While a large fraction of recurrent and/or conserved mutations can directly or indirectly be considered NAMs as they typically perturb signaling networks (as exemplified here with BRAF V600E) and they typically operate as functional driver mutations, in this study we have demonstrated that non-recurrent and non-conserved mutations also can be functional NAMs.
On the other hand, AM fungi form hyphal networks which operate as functional extensions of the plant root system (Smith & Read [2008]).
Instead the authors were provided with a list of 1,033 PSCs with no information as to when they were established and whether they are still operating or functional.
The tissue organization is also consonant with the proposal that those units can operate as functional analogues of muscle spindle organs.
It remains unclear how these brain regions operate in functional networks, and whether proactive and reactive inhibition depend on common networks, unique networks, or a combination.
These findings suggest that hD2R and hSSTR2 operate as functional heterodimers modulated by ligands in situ, which may prove to be a useful model in designing new therapeutic drugs.
Any digital leader missioned with company-wide transformation must be able to bring a horizontal purview to the organization and operate across functional silos.
