The purpose of this study was to evaluate alphaB-crystallin with respect to clinicopathological parameters and the outcome of patients with operable high-risk breast cancer.
In operable high-risk breast cancer, alphaB-crystallin protein expression is associated with poor prognostic features indicating aggressive tumor behavior, but it does not seem to have an independent impact on patient survival or to interfere with taxane-based therapy.
In conclusion, this single-study analysis of 3754 patients demonstrated that only severe obesity (BMI ≥ 40) is associated with worse outcomes in operable high-risk early breast cancer, especially in the triple-negative subtype.
To be eligible for inclusion in the trials, patients had to have operable, high-grade OS and not to have other medical conditions which might preclude them from receiving treatment according to the protocol, and the maximum interval from biopsy to randomisation was 35 days (Bramwell et al, 1992; Souhami et al, 1997; Voûte et al, 1999).
In addition, the design of chip-holders which are operable at high temperature, pressure and have a high chemical resistance further extend the operability of chip-based microreactors for use in the special chemical industry.
The present study revealed the importance of stringent controlling of the additive level for maintaining a balanced bifunctional behavior of the catalyst combination through the synergistic effects by the components and the need of a proton conducting membrane operable at high temperature to get better output from the Polymer Electrolyte Membrane Fuel Cell (PEMFC) systems.
Conclusions: In this multicenter study encompassing 2992 patients with operable LC, a high frequency of comorbidity has been found, COPD occurring most frequently.
In this study, an operable process for high starch accumulation in duckweed was developed, paving the way for large-scale treatment of wastewater and the application of duckweed to bioenergy.
The impact of immunotherapy was initially demonstrated in patients with advanced cancer and then translated to the adjuvant setting of patients with operable disease at high risk for postoperative recurrence [ 70].
This important result indicates that the relief of glucose repression in the wild-type is already operable at much higher glucose concentrations than is currently widely accepted and that the phenotype of the respiratory strain is glucose insensitive by comparison.
