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This approach adds significant value to method development by defining and understanding critical method attributes, critical method parameters, and method operable design region.
Resulting contour plots enabled to establish the design space (DS) (method operable design region) where all CQAs fulfilled the requirements.
In this paper an operable design of open benchmark database is studied and proposed with emphasis on administration, availability, data reliably, unified data standards and open system architecture.
Developing the QC-method in accordance with the Quality by Design guidelines gives the possibility to do continual improvements inside the original Method Operable Design Region (MODR).
Chromatography software is employed to effectively generate design spaces (Method Operable Design Regions), which are subsequently employed to determine the final method conditions and to evaluate robustness prior to validation.
The optimum point into MEPS-Method Operable Design: Region (MODR) was obtained with R-CX sorbent, acetonitrile (ACN) as elution solvent, three loading cycles and 500 μL of sample volume.
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The methodology provides the decision maker with information about a number of operable designs and an understanding of the performance risks associated with the selection of any given design.
The SSMR is an indoor/outdoor remotely/autonomous operable vehicle designed for research in combination of autonomous and man-machine control of mobile robots with application of telepresence principles.
In order to design more operable or even optimal chemical processes, reliability theory is proposed in this paper to support planning of operating procedures.
The heating of the fuel pins was carried out using a specially designed remotely operable furnace, which allowed localized heating of about 100 mm length of the fuel pin at one end under flowing argon gas or in air atmosphere.
"Building, flying, landing, and re-flying New Shepard has taught us so much about how to design for practical, operable reusability.
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