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When paired opposite cytosine in duplex DNA at physiological pH, M1dG undergoes ring opening to form N- 3-oxo-1-propenyl -dG (N- 3-oxo-1-propenyl -dG
The hemiketal intermediate can undergo ring opening to form a negatively charged phosph on)ate, which subsequently delivers the free phosph on)ate nucleoside after spontaneous β-elimination.
In the MS/MS spectrum of the tetrahydroprotoberberine alkaloid, tetrahydropalmatine (Fig. 3), the predominant ions at m/z 192.1013 and 165.0887 result from RDA C-ring opening to form tetrahydroisoquinoline fragment ions.
Muscle fibres loop around the urethral opening to form the internal sphincter, which is under involuntary control.
At low pH, the N-4 atom on the 1,2,4-oxadiazole ring is protonated, followed by nucleophilic attack on the activated methine carbon to cause ring opening to form aryl nitrile degradation product, compound B. At high pH, the nucleophilic attack occurs on the methine carbon to generate an anion on N-4.
Previous studies have shown that placing cytosine opposite M1dG in duplex DNA at pH 6.8 results in ring opening to form N-OPdG (29).
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The structure draws upon the shape of a traditional Malay umbrella, opened to form a blue angular dome and closed to form a minaret.
And the incredible, which was also the inevitable, now took place as negotiations opened to form the first non-communist government in Soviet Europe.
Mercator produced the simplest and, for its purposes, the best solution by in effect converting the spherical Earth into a cylinder with the open ends at the poles; this cylinder was then opened to form a plane surface.
The deposited fullerenes are opened (to form open caps that serve as nucleation centers) and then activated by functionalization.
Then the rings of saturated aromatics are further selectively opened to form products with high CN.
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