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Each take values restricted within the interval [ 0, 1 ] reflecting opening probabilities.
Fig. 7F shows opening probabilities of VGSCs recorded from the soma (left, 0.055±0.015) and axon (right, 0.13±0.013; p<0.13±0.013
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Dependence of kinetic parameters on DNA thermal opening probability.
Open probability determined this way was further used to calculate Keq.
A few reasons could be responsible for the sublevels and rectification of I323T: the brief opening, low open probability, and disruption of cooperativity of the four I323T subunits.
Open probabilities (Po) of the BK channel were measured using the cell-attached patch clamp technique.
A single-channel current-voltage relationship, and open probabilities are presented in Fig. 6 (A C).
All mutant channels had higher basal open probabilities, which limited their further increase by agonist or hypotonicity.
A strong correlation was observed between clinical severity and an increase in the deduced basal open probabilities.
Ion channel open probabilities (NPo) are normalized to control.
Single-channel amplitude and open probabilities were determined from amplitude histograms at each potential.
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