Sentence examples for opening of the active from inspiring English sources

Loop 13 14, which folds on top of loop 5 6, probably plays an important role in stabilizing the placement of loop 5 6, and hence the closure of the active site, as only TMHs 13 and 14 move horizontally during the conversion from the IDP- to Pi2-bound states (Fig. 3b). Figure 3: Movements associated with constriction and opening of the active site.

The opening of the active site presumably also decreases the affinity of the active site for product (MgPi), allowing the second phosphate to leave the active site, and thus returning the enzyme to the resting state (M-PPase:Mg2; Fig. 5a).

Conformational analyses, theoretical reactivity models and docking experiments in PBP2a cavity allow to propose a novel pharmacophore, i.e. the 3- S -acylamino-1-acyl-2-azetidinone ring, with the syn-conformation of the imide function, associated to a flexible macrocycle favoring the opening of the active site.

These studies reveal two conserved residues (C286 and R339) present at the opening of the active site of AgAChE but absent at those of mammalian AChEs.

Located on the opposite side of R339, C286 has favorable sulfur-aromatic interactions [17] with W280 and Y333 both located at the opening of the active site (Figure 4).

A sequence analysis of AChEs from 73 species and a three-dimensional model of a malaria-carrying mosquito (Anopheles gambiae) AChE (AgAChE) reported here show that C286 and R339 of AgAChE are conserved at the opening of the active site of AChEs in 17 invertebrate and four insect species, respectively.

[Rodríguez et al. (2010)] clarified by site-directed mutagenesis of Arg48 and Glu71 in LpPAD that the entrance region, particularly the β1-β2 and β3-β4 loops, adopted a distinct closed conformation that decreased the opening of the active-site cavity.

The bulky, aromatic portion of compound 2 occupied the hDAAO subpocket and stabilized an opening of the active-site lid.

This suggests that the mechanism of improvement comprises a nonspecific "opening up" of the active site such that it better accommodates environmental estrogens of any size.

Second, we also found that a large conformational change occurred to the Trp86-containing helix after 50 ns of our simulations of HI-6sarinnonaged-mAChE, which could relate to the reported back door opening of the AChE active site [33], [34] or indicate an artefact of the simulation protocol that has not been evaluated rigorously for simulations longer than 20 ns.

Residues mutated in (A ) are involved in stabilizing the active dimer, whereas residues in (B ) couple the dimer formation to the opening of the activation segment.