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"I think that Pride has opened the significance of this story for the young generation in Wales and further afield – many of whom wouldn't remember the strike but would now be thinking: "Well my grandfather used to work in the collieries... and what was that all about?" said Dai Donovan, Welsh miner turned trade unionist.
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"The significance of 'The Sopranos' is that it opened the door for the executives to take a chance," she said.
Last year, Cranston himself opened up about the significance of wearing tighty whities on the small screen.
Emerging reports of shared molecular alterations between LCIS and adjacent invasive lesions in parallel with genomic evidence that LCIS may be one of several early identifiable lesions in the pathogenesis of low-grade cancer have re-opened the debate regarding the true significance of LCIS and its precursor potential.
Of increasing significance, digitized databases open the way for a much wider distribution of the maps over the Internet.
I think it's kind of a viewing and permission to open the door, and there's some significance to the red door," La Deaux says.
In the debate that has now opened, of great significance to the development of British democracy, I suggest that British journalists make use of the experience compiled by a non-profit organisation here: Investigative Reporters and Editors was formed by journalists in 1975.
Open the balloon opening.
If the real impact of social media in the Arab Spring was open to question, the significance of WikiLeaks was not.
Nonetheless, concentrating on the rank correlation test, it is still an open question whether the significance level is satisfactory in the case of a continuous outcome variable.
Taken together, our analyses of the diversity and evolution of the potential replication origins in haloarchaea may open avenues to understanding the significance of the multiple replication origins in the domain of Archaea.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com