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The mean Org 25435 concentration at which eyes were opened on command was 4462 ng/mL (median 4679 ng/mL).
For subjects 9-19 belonging to dose groups 3 and 4 mg/kg an arterial blood sample was taken at the time at which the eyes were opened on command.
Based on the mean Org 25435 concentration occurring at the time at which eyes were opened on command, a concentration of 5000 ng/mL was chosen as the target concentration for the first subject in the TCI study.
The initial target concentration was based on the mean Org 25435 concentration occurring at the time at which eyes were opened on command in the short infusion study and evaluated using simulation to ensure that the total dose received (including any upwards titration), did not exceed 1.5 times the maximum dose given in the Short Infusion study.
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THE gate to the pristine estate swings open on command — an internally generated command.
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The 5 anaesthetised subjects opened their eyes on command at 13.7 minutes and moved their limbs on command at 16 minutes after the TCI had finished, data are means.
At the end of surgery, the desflurane was stopped and extubation was performed when the patients began breathing spontaneously and could open their eyes on command.
The command screen will open on the desktop.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com