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It was the first time Republicans had shown themselves open to significant amounts of new taxes.
This procedure leaves them open to significant changes by MPs, unlike the customary procedure of publishing detailed bills which the government then seeks to pass in their entirety.
They might even lead to a governing coalition that is hostile to the loan agreement that Germany has insisted is not open to significant renegotiation.
Over the past few weeks, Iranian officials have sent signals that they would be open to significant compromises on the nuclear programme that could pave the way to a deal.
For example, we've had investors come to us with concentrated equity positions, leaving them open to significant financial damage if that company goes out of business or falls precipitously in value.
However, Deputy Domaille said this was earmarked to improve defences at three key areas - Belle Greve, the Bridge and Perelle - identified in a report as open to significant coastal flooding so could not be used for the repair work.
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The film premiered at the Cannes Film Festival, and opened to significant controversy and criticism from audiences and critics.
EADS left the door open to further significant charges later this year, saying that the "range and magnitude" of the write-downs would be known only after A400M contract renegotiations were completed near the end of 2009.
Doctors performing ultrasound on patients without completing their credentialing open themselves to significant liability risks irrespective of the frustration the perceived barriers may cause them [18].
Understanding the metabolic role of different ALDH isoform in the control of stem cell phenotype and cell fate during development, tissue homeostasis, or repair, as well as carcinogenesis, should open perspectives to significant discoveries in tissue biology.
(It also opened TechCrunch to significant legal liability).
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CEO of Professional Science Editing for Scientists @ prosciediting.com