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The opening end may be either easy open (ring pull) or classic (can opener needed) (Oldring & Nehring 2007).
Under visible light, the combination molecule is in the form of an open ring; it closes up under ultraviolet.
Surprisingly, we indicate that PKS/NRPS releases its product with an open ring structure, probably as an alcohol.
The parent isoxazole compound is converted in vitro and metabolized in vivo to an open ring isomeric form, SU0020.
An open ring feeder distribution system is considered to evaluate the performance of the proposed protection scheme.
On the same monomer, Val123 forms also a third hydrogen bond with the oxygen atom on the open ring of KH176m.
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The photochemical behavior is perturbed by a resonant quinoid structure which stabilizes the open-ring isomer.
This result strongly suggests that the open-ring forms of Y494D mutant (and also possibly open-ring forms of ΔN-TClpB) are responsible for the high intrinsic disaggregation activity.
The two representative states (closed- and open-ring states) can be quantitatively distinguished by measuring circularity (Supplementary Figure 7a).
It turns out that the topology of the open-ring form's LUMO is correlated to the (non- photochromic character.
Strikingly, the hyperactive Y494D mutant exhibited mostly open-ring oligomers (Fig. 4d) and a small amount of closed rings (Fig. 4e).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com