Sentence examples similar to open loci from inspiring English sources
CIP reorganizes the somatic genome to an intermediate state that is resolved under 2iL condition by re-closing previously opened loci prior to pluripotency acquisition with gradual opening of loci enriched with motifs for the OCT/SOX/KLF families.
In this context an unanticipated, potent property of serial Flp-RMCE setups concerns the potential to re-open loci that have served to establish the iPS status before the site underwent the obligatory silencing process.
The availability of the complete genomic sequences of the human and mouse T cell receptor loci opens up new opportunities for understanding T cell receptors (TCRs) and their genes.
Transcriptional activity might keep the chromatin locus "open", thus providing permissive conditions for gene re-activation upon removal of Dox.
In the present case enhanced transcription of PCA3 may open up the locus and in turn increase the level of BMCC1 transcription.
In addition, the validation of these loci opens the way for their fine mapping and their cloning, which will improve our understanding of the molecular mechanisms underlying partial resistance.
In particular, it is an open question whether locus-specific ancestry can be accurately inferred on very close populations such as mixtures of Asians, or mixtures of Europeans (e.g. Americans of European descent).
CNV: copy number variation; EBI: European Bioinformatics Institute; GEN2PHEN: Genotype-To-Phenotype Databases Project; HGVS Human Genome Variation Society LOVDVD: Leiden Open Variation Database; LRG: Locus Reference Genomic; LSDB: Locus-specific Database; NCBI: National Center for Biotechnology Information.
Vice versa, this model would predict that Wt1 activity is not instructive; even if it opened up a locus, the expression of the locus would still depend on another signal.
Several loci with open reading frame changes also had altered transcript abundance.
Moreover, both loci harbor open reading frames for HML-2 Rec and Env-like proteins.
