The C-terminus can undergo large conformational changes between a closed, ligand-bound structure, and an open, membrane bound structure that enables phospholipid binding and release [ 20].
Such sites in high LD within a region of open chromatin bound by proteins that assemble an enhancer complex could all jointly contribute to the statistical signal.
His first shot was stopped by the Spaniard who was, however, unable to get in the way of an open goal bound second effort.
If the blue clay disrupts players' preparation for Paris, the quality of tennis at the French Open is bound to suffer.No doubt, a yellow ball is easier to see against a blue background than against a washed-out red.
And, spring after spring, I watch as girls with corn-silk hair soar off campus in open cars, bound, I imagine, for supernal débutante parties, nymph dances amid rolling pastures beyond the last commuter stop, in some mystic arch-suburb that is the real Pennsylvania.
AP-2 can transition between metastable states; a partially open form bound to the dileucine sorting signal has been characterized (Kelly et al., 2008).
DOI: http://dx.doi.org/10.7554/eLife.00411.013 In the RC-RF1 map we observe RF1 in an open conformation bound to the unrotated, MS-I state ribosome, in accordance with the results of earlier studies of this complex (Petry et al., 2005; Rawat et al., 2006; Laurberg et al., 2008).
R-open holds bound polypeptide via hydrophobic contacts with at least helix I and the underlying segment, which still face the cavity, while simultaneously presenting binding sites for the GroES mobile loops at the correct positions for GroES docking.
The receptors 7a and 9a having open structures bind to fluoride ion with good affinity.
In one scenario, dynamin oligomers, too short to form complete circles or helices and thus shaped as open arcs bind to the curved membrane of a nascent fusion pore rim.
