Exact(24)
The open binding groove of MHC-II molecules can bind peptides of variable sizes.
Prediction of MHC-II epitopes is particularly challenging because the open binding cleft of the MHC-II molecule allows epitopes to bind beyond the peptide binding groove; therefore, the molecule is capable of accommodating peptides of variable length.
Prediction of MHC-II epitopes is particularly challenging because the open binding cleft of the MHC-II molecule allows epitopes to bind beyond the peptide binding groove; therefore, the molecule is capable of accommodating peptides of variable length [ 1].
The design and synthesis of coordinative supramolecular polygons with open binding sites is described.
They included a proposal to open binding arbitration sessions to public participation and an overhaul of the county's disability retirement system.
It is designed to allow for an open binding architecture that enables BizTalk Server to easily integrate into a mixed environment.
Similar(36)
The docking was then repeated on this opened binding site against the ZINC Drugs Now database [63], which yielded very good inhibitors of MurA enzyme as three of the highest scoring compounds that were biochemically tested for their inhibitory ability showed lower than 1 µM IC50 values and are now subject for further optimization and research (in preparation).
In CDKs, phosphorylation of the T-loop triggers major conformational changes that open ATP binding pocket and a substrate binding site making CDKs fully active as a kinase [ 59].
However, it remains open, whether binding of Ca2+/CaM to STIM2 K-rich domain can terminate an existing ER PM contact in vivo or whether Ca2+/CaM binding has to occur before binding of STIM2 to PM lipids.
In the same way that companies have developed policies around sustainability, they now need open and binding strategies around their female employees.
In addition, conformational rearrangements are seen in a disulfide bridged surface loop (Cys141 Cys148), which moves inwards, partially closing the open substrate binding cleft of the native enzyme.
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