Sentence examples for open active from inspiring English sources

This study confirmed the ability of dasatinib to bind to ABL kinase when the activation loop is in the open (active) conformation, thus confirming the theoretical potential for dasatinib to override imatinib resistance.

However, the majority of imatinib-resistance mutations occur in the activation loop, locking it into the open (active) conformation, which precludes imatinib binding.

Dephosphorylation of Tyr527 converts Src to an open active conformation and triggers autophosphorylation of the activation segment residue Tyr416 to yield a fully activated enzyme.

The five hnwd genes encode for proteins of the STAND class thought to act as molecular switches with a closed inactive form and an open active form adopted upon binding to an activating molecule [ 26, 27].

The activation loop of ABL kinase oscillates between open (active) and closed (inactive) conformations.

A number of Src SH2 domain inhibitors enhance the kinase catalytic activity by switching the closed inactive to the open active conformation.

The clinical examination included the assessment of painful areas that have been subjectively reported by patients, the qualitative assessment (presence of any deviations or deflections) and quantitative analysis of vertical movements of the jaw (open active pain-free, fully open active, passive maximum opening, and evaluation of overbite).

A significant axial movement of the α7 helix is associated with the open, active conformation of integrins.

The more open active site architecture of RgDAAO is the origin of its much broader substrate specificity.

Structural modeling suggests that the relatively open active site of DinB is enclosed by interaction with these proteins, thereby preventing the template bulging responsible for -1 frameshift mutagenesis.

The larger and much more open active site architectures of 2C9 may explain the weaker inhibitory affinity of chrysin towards 2C9.