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Multicellular development requires that the basic processes of cell growth and proliferation be subjugated to a higher level ontogenetic program.
The changes in axon growth ability of PCs at different developmental stages could be the expression of an intrinsic ontogenetic program that progresses regardless of external influences.
Speciation is not a built-in stage of the species ontogenetic program.
In animal development following the initial cleavage stage of embryogenesis, the cell cycle becomes dependent on intercellular signaling and controlled by the genomically encoded ontogenetic program.
On the other hand, the marked effects of the first 4 days of life (NN-DMRs relative to PN-DMRs) suggest strong environmental effects in addition to the predefined ontogenetic program.
Conventional (within-generation) plasticity is a genetic mechanism that allows a genotype to produce different phenotypes in different environments, either via changes in the ontogenetic program that lead to a different phenotypic end-point (developmental plasticity), or as an environment-dependent response within a developmental stage (phenotypic plasticity).
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Therewith, other ontogenetic programs, first of all body growth, can also be retarded.
These ontogenetic programs can be summarized as differences in the rate or timing of different aspects of development.
Reproduction is largely a matter of creative force of the ontogenetic programs; multiplication is largely a matter of contingency.
It is not yet clear how important the differences are between treating Baldwin effects in terms of individual ontogenetic programs versus population level dynamics.
In the Ecdysozoa, a vast variety of ontogenetic programs lead to the specification of the endoderm and its differentiation into a functional gut, mostly influenced by the particular ecological and developmental adaptations of each organism.
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