Pathway knowledge bases represent the careful collection of genes and their interactions, mapped onto biological processes.
Properties of yeast genes and their interactions were labeled onto these modules to facilitate interpretations, including essential genes, protein interactions, synthetic lethal interactions, and protein complexes [ 21, 22, 24].
Absence of 67 and 50 kDa isoforms under all immunoprecipitation conditions confirmed their adherence onto hydroxylapatite due to their strong interaction (ABC domains) with the matrix.
Once that happens, he said, "you can piggyback social behaviors onto the interaction, like eye contact, joint attention, turn taking, things these kids have trouble with".
For example, two microarray data sets can be mapped onto an interaction network to analyse gene repression or activation when different experimental conditions are studied.
However, when mutations are mapped onto protein interaction networks, they fall onto a relatively conserved set of oncogenic modules.
As the most intuitive and straightforward expression feature, differential expression statistics are often overlaid onto protein interaction network, and subnetworks enriched for differential expression genes are fetched [ 7- 11].
After submitting the list of identifiers, the application maps them onto an interaction network (Section 4), and computes topological properties for the entire network, the uploaded gene/protein set and random sets of matched sizes.
I believe that this App will be highly useful to researchers working with transcriptomics and proteomics data, as these often have a need to display, for example, expression time-courses onto protein interaction networks.
However, since protein structure data are limited, it is impossible to project all structural information onto protein interaction datasets, and, as a result, the number of distinct binding interfaces of a hub may be underestimated.
