The subgroup analysis allowed the comparison of treatment versus placebo groups in monkeys that had a more rapid onset and severe disease while removing those monkeys with later disease onset from the analysis.
At the onset of the analysis, we dichotomized postnatal steroid application (none vs. any, Table 2).
†Controlling for age (in months), month and year of birth, and month of illness onset in the analysis.
To include the development of cancers prior to SSc onset in the analysis, these event times were rescaled by subtraction of the smallest observed event time (that is, -22 years).
Specifically, concerns about using fixations as onsets in the analysis of fMRI data relate to two temporal properties of fixations: first, they are relatively short (∼200 300 ms) and, secondly, they usually occur at a relatively high rate (∼3 4 per second), only split by short saccades (∼20 30 ms) during which no visual information is picked up.
This observation, together with the extensive transcriptional onset observed in the analysis of functional ontology categories in viral treatments (see below), follows that of Abbas et al. (2006) suggesting that a specific immune response mobilizes more transcriptional remodelling than the majority of physiological responses.
Only samples taken within 7 days of symptom onset were included in the analysis.
Additionally, events for which the participants were awake in the epoch preceding train onset were excluded from the analysis.
The onset age used in the analysis for these conditions was the date of first diagnosis, not the date of first medication use.
Those with diagnosis codes for gestational diabetes mellitus in the year before or after HT onset were excluded from the analysis.
For the analysis, onset of proteinuria, the day of peak UPCR, and day of lowest platelet count, was rescaled from the DDf, considering DDf as day 0. Statistical analysis was performed using SPSS software version 17 (IBM Corporation, Somers, NY, USA).
