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Many autistic subjects display a dysregulation of the immune system which is compatible with an unresolved viral infection with prenatal onset, potentially due to vertical viral transmission.
Finally, we excluded cases whose onsets coincided with the primary onset, potentially missing some transmissions.
Infectious causes can have long durations of onset, potentially requiring several presentations for care, incurring direct and indirect costs for women and families several times over.
This finding suggests that examining the general health of people with and those without disabilities might mask differences associated with onset, potentially relating to differences in experience and self-perception.
Acute gastroenteritis (AGE), defined as diarrheal disease of rapid onset potentially accompanied by nausea, vomiting, fever, or abdominal pain, is a major cause of illness in the United States.
In contrast, findings have been inconsistent among previous epidemiologic studies that examined late pubertal milestones rather than pubertal onset (potentially a more sensitive end point) and have been limited either by small sample size, cross-sectional design, self-reported pubertal staging, or lack of an exposure biomarker.
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Hemophagocytic lymphohistiocytosis (HLH) is a rapid-onset, potentially fatal hyperinflammatory syndrome.
Finally, two common variants for T1D, an early-onset, potentially lethal disease, have been described as neutrally evolving [ 32].
The "fetal programming hypothesis" for instance suggests that conditions very early in human development, even in utero, can leave lasting imprints on a person's physiology and mental health - these imprints may 'affect susceptibility to diseases' with onsets potentially occurring many decades later [ 66– 66].
This is crucial to avoid the onset of potentially severe complications that are especially serious in elderly and debilitated subjects.
Their incidental detection may anticipate the diagnosis before the clinical onset and potentially warrant higher survival rates, as suggested by Konnak et al. [16].
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