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However, optimising directness of a study to policy questions can often be considered from the onset of study design (in balance with the degree of experimental control).
There was no significant difference regarding age, gender and EDSS distribution between patients with CIS-RRMS and CIS-CIS at onset of study (Table 1).
Visit 1 corresponded to the onset of study therapy.
Overall survival and time to progression were measured from onset of study treatment until death or disease progression, respectively.
A total of 275 young adult (14 weeks of age at onset of study) female Sprague Dawley rats were randomly divided into 10 groups.
Biopsy specimens from metastatic lesions were taken from 12 patients prior to the onset of study treatment with written informed consent.
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Before the onset of the study, information about the study was sent to parents.
Therefore, it is critical to facilitate constructive dialog and partnership among laboratory and field researchers and study participants from the onset of the study to ensure its success.
With the exception of Brown et al. [ 24], who excluded participants with depressive episodes within 3 years before the onset of the study, none of the other studies in this meta-analysis excluded people who had had depression at some point during a lengthy period before the onset of the study.
Furthermore, the study participants were not on selenium-containing supplements prior to onset of the study and agreed not to take selenium containing supplements throughout the study period.
At the time of the onset of our study, only the trials included in our study were published.
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