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This is also supported by the dose-dependent effect of stressors on the onset of disorders [ 5].
First, the onset of disorders such as schizophrenia frequently occurs during or just after puberty (2, 3) suggesting that sex steroid-triggered maturational changes in the brain may unmask vulnerability (4, 5).
However, the outcome groups at age 3½ years were not diagnoses, but strictly using DSM-IV criteria may underestimate clinically significant symptoms which might represent later onset of disorders [ 55].
From a public health perspective, the burden of disease associated with first onset of disorders after early adulthood is far less than that posed by recurrence of these disorders (or worsening of symptoms) throughout the rest of life.
Individuals experiencing early onset of disorders categorized as "F20 F29: Schizophrenia, schizotypal and delusional disorders" may already show typical symptoms upon admission to CAP care at an age of 13 17.
50 51 A great limitation of current epidemiological and clinical research on dementia has been its focus on cohorts over the age of 65, so that reliably estimating the extent of exposure to subclinical states before the onset of disorders such as depression and diabetes or determining the age at which intervention and prevention are most likely to be maximally effective has been impossible.
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Patients in the respiratory subtype were characterized by a later onset of disorder and a family history of PD.
In each instance, the timing of first onset of disorder or suicidal behavior was recorded.
The findings are highly suggestive that alterations in reward processing are present in high-risk youth before the onset of disorder.
Reasons for this are unknown, but returning to the family home following the onset of disorder for health care and social support may provide a possible explanation.
Patients with a depressive presenting polarity were younger both at onset of disorder and at study entrance than those with an elevated presenting polarity.
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