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In the LFP, the onset of component 2 led to a profound attenuation of oscillation strength in most of the cases.
As a control for effects related to the sudden onset of component 2, we have done experiments for which component 2 appeared gradually (Supplementary Fig. 1).
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To do so, we first summed the estimated time courses from each individual trial epoch (cue + response preparation + saccade response) in each voxel of the brain, shifting the response preparation epoch time course by 1.5 s to account for the onset of this component in a trial and the saccade response epoch time course by 3 s.
Evidence for differing effects between artificial and natural reading situations are only beginning to emerge, but first studies point to an earlier onset of electrophysiological components under natural conditions (Dimigen et al. 2011), most likely resulting from parafoveal lexical preprocessing (Reingold et al. 2012).
To determine whether the decrement in activity was specific for the P3 component, a second analysis was performed with a baseline from −200 to the onset of the P3 component (i.e. 680 ms).
To test this idea, we developed a paradigm in which the onset of the second component of a plaid was delayed relative to the onset of the first component.
When HFS was given at the onset of the R2 component of the blink reflex, HFS induced a lasting facilitation of subsequent R2 responses (HFSLTP).
HFS was repeatedly given directly at the onset of the R2 component of electrically evoked blinks to induce LTP like plasticity (HFSLTP) in patients and controls.
Separate control experiments were conducted only in controls and included HFS shortly before the onset of the R2 component (HFSLTD) and a non-intervention protocol (HFSNO).
Martens et al. [42] reported an earlier onset of the P3 component, associated with working memory updating, in subjects with little behavioural competition between visual targets.
HFS given at the onset of the R2 component of the blink reflex (HFSLTP) produced a lasting facilitation of the R2, whereas HFS given shortly before R2 (HFSLTD) caused a lasting suppression of the R2.
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Justyna Jupowicz-Kozak
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