The suspected ADRs documented in an SRS such as EudraVigilance are highly dependent on the reporter's ability to recognize them as such, and some characteristics are helpful in this respect: biological concordance with the drug mechanism of action, a short time to onset, a positive dechallenge and lack of alternative causes.
Without further evidence close to onset of the disorder, these alternatives cannot be distinguished.
The moment he says anything bracing, the touchy energy markets will probably panic, pushing prices even higher and thereby hastening the onset of recession, a switch to alternative fuels or new conservation efforts -- or all three.
They find that earnings declined by 50percentt within two years after onset of a work limitation and alternative income sources such as UI benefits can only partially offset the decline of earnings.
With the onset of the increased awareness concerning alternative therapies, everyone now has more options to improve their health and well-being.
Clearly, mechanisms for adipogenesis and onset of obesity are complex, and alternative pathways can compensate for the inhibitory effects of ENPP1 on adipogenesis.
These findings suggest that another location of control for the regulation of onset of cell death exists, and alternative mechanisms have been proposed.
However, they also suggested that some flat neoplasias may progress to de novo cancers with LOH at chromosome 3p, the location of hMLH1, and this could explain the onset of MSI-H as an alternative mechanism to hypermethylation of the promoter of hMLH1.
The unprecedented intron gain at the onset of animal evolution could further contribute to the expansion of alternative forms.
In response to defective clonal deletion in the thymus, we observed compensatory induction of alternative tolerizing mechanisms that might prevent earlier onset of autoimmunity in BH3 Tg mice.
