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Each trial began with the onset of a small fixation target.
From left to right, trials began with the onset of a small dot that the monkey was required to fixate for 150 ms. Next, two saccade targets (hollow gray circles) appeared for 250 ms. The two targets were 10 degrees eccentric from the visual fixation point and 180 degrees apart from each other.
Assessing changes in intraepidermal nerve fiber density (IENFD) is emerging as a powerful technique for accurately diagnosing and staging the onset of a small fiber neuropathy in patients [ 23] and animal models [ 24, 25].
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A series of spectropolarimetric observations obtained in 2010 with the Bernard Lyot Telescope at Pic du Midi Observatory revealed the presence of a weak magnetic field at the surface of Betelgeuse, suggesting that the giant convective motions of supergiant stars are able to trigger the onset of a small-scale dynamo effect.
Our previous study found an earlier age of disease onset in a small cohort of ALS patients (n = 65), when comparing those bearing a longer ATXN2 repeat to those with a normal length repeat [31]; it is possible that those data were driven by patients with 3CAA interruptions in the repeat sequence, of the GT haplotype.
Airò et al. also reported a clustering of cancers with SSc onset in a small sample of patients with anti-RNAP antibodies [ 7].
The increase in CD40-positive cells was specific for DCs and involved the subset of myeloid and CD8α+ DCs before disease onset, with a small involvement of plasmacytoid DCs in diseased mice.
The aim was, firstly to predict the failure loads (critical loads) originating the first debond onset in a small bundle of fibres and, secondly, to verify the unstable character of subsequent debond growth under transverse loads.
The time of onset showed peaks at 4 months (33.7%) and 8 months (11.4%) after starting AI administration, and there was onset in a small number of patients even after more than 13 months.
Airò et al. also described similar clustering of cancer associated with the onset of SSc in a small sample of patients [ 7].
Thrombectomy leads to a significant decrease in previously known migraine, and new onset of headache in a small subset of patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com