Exact(21)
Pancreatic neuroendocrine tumor (PNET) is a rare type of malignancy [1], with an estimated prevalence of 2.23/100,000 and annual onset incidence of 1.01/100,000 in Japan [2].
5 Time of onset, incidence, location and severity of clinical manifestations all exhibit inter-individual variation.
In patients with the longest history of metformin use prior to cancer onset, incidence tended to be lowest.
Feline mammary carcinoma is similar to human breast cancer in the age of onset, incidence, histopathologic features, biologic behavior, and pattern of metastasis [ 9, 10].
A natural inhibitor of cysteine proteases is cystatin C. Cystatin C-deficient, sufficient and heterozygous mice were tested for onset, incidence and severity of CIA.
This analysis was performed to increase the likelihood of detecting and characterizing differences in the onset, incidence, or duration of adverse events (AEs) between the two formulations.
Similar(39)
An early-onset incidence pattern has been described for cervical [ 24] and ovarian cancers [ 25], and whether human papillomavirus and hormonal factors, respectively, are risk factors for small cell carcinoma of these sites remains to be determined.
Similar to the IR pattern previously described for medullary breast cancer, a predominantly ER-negative tumor [ 26], we found an early-onset incidence pattern for breast-ACC - a rapid rise in incidence at young ages with falling or flattening incidence rates after midlife.
In contrast, late-onset incidence patterns - as exemplified by papillary and mucinous breast cancers, typically ER-positive cancers of presumed luminal origin - are characterized by a progressive rise in incidence with advancing age, possibly due to lifelong carcinogenic events and/or exposures [ 16, 26].
After additional adjustment for age at diabetes onset, ESRD incidence was similar in the two groups (incidence rate ratio 1.38, 95% CI 0.45 4.24).
Late onset disease incidence estimates based upon community population denominators (Dominican Republic) may also have under-estimated incidence.
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